Datura stramonium, also known as Jimson Weed, Devil's Trumpet, Thorn Apple, and Moonflower, is a common weed in the nightshade family. It has a history of use in traditional medicine for its pain-relieving and healing properties, but its highly toxic nature requires extreme caution. All parts of the plant contain powerful mind-altering compounds that have been used to calm schizophrenic patients, but the difference between a medicinal and toxic dose is very small. The plant is widely spread across warm and moderate regions of the world and can be found along roadsides and in garbage dumps. The fragrant flowers, which emit a pleasant fragrance at night, are trumpet-shaped and fed upon by nocturnal moths. The plant has been used in sacred ceremonies by various indigenous people across the Americas to achieve intense hallucinations and visions. Careful use and supervision by a qualified practitioner are critical to minimize harm.